In silico prediction of serious eye irritation or corrosion potential of chemicals

In silico prediction of serious eye irritation or corrosion potential of chemicals

Rapidly and correctly identifying eye irritants or corrosive chemicals is an important issue in health hazard assessment. The purpose of this study is to describe the development of in silico methods for the classification of chemicals into irritants/corrosives or non-irritants/non-corrosives. A total of 5220 chemicals for a serious eye irritation (EI) dataset and 2299 chemicals as an eye corro...

prediction of ignition delay period in d.i diesel engines

a semi-empirical mathematical model for predicting physical part of ignition delay period in the combustion of direct - injection diesel engines with swirl is developed . this model based on a single droplet evaporation model . the governing equations , namely , equations of droplet motion , heat and mass transfer were solved simultaneously using a rung-kutta step by step unmerical method . the...

Skin irritation and corrosion.

Eye irritation potential: usefulness of the HET-CAM under the Globally Harmonized System of classification and labeling of chemicals (GHS).

Extensive research has been conducted over the past decades to develop alternatives to the rabbit eye irritation test (Draize test) used in a regulatory context to assess eye irritation potentials. Although no single in vitro test has emerged as being completely acceptable for full replacement, various tests are considered to be suitable and are regularly used to assess certain aspects. Amongst...

Subgroup 2 . Skin Irritation / Corrosion

ECVAM, Institute for Health & Consumer Protection, European Commission Joint Research Centre, 21020 Ispra (VA), Italy; EVIC FRANCE,33290 Blanquefort, France; Syngenta, Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK; SEAC, Unilever Colworth Laboratory, Sharnbrook Bedfordshire MK44 1LQ,,UK; ZEBET BfR, Diedersdorfer Weg 1, 12277 Berlin, Germany; TNO Nutrition & F...